Molecular mechanisms of Nrf2-mediated antioxidant response
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of Nrf2-mediated antioxidant response.
Nrf2 is the key transcription factor regulating the antioxidant response. Nrf2 signaling is repressed by Keap1 at basal condition and induced by oxidative stress. Keap1 is recently identified as a Cullin 3-dependent substrate adaptor protein. A two-sites binding "hinge & latch" model vividly depicts how Keap1 can efficiently present Nrf2 as substrate for ubiquitination. Oxidative perturbation c...
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ژورنال
عنوان ژورنال: Molecular Carcinogenesis
سال: 2009
ISSN: 0899-1987,1098-2744
DOI: 10.1002/mc.20465